Micky van de Ven Double Ends Everton's Run at Brand New Stadium
The Dutch defender became the initial backline player to net twice in a English top-flight match for Tottenham since the Belgian defender in March 2013.
Key points
The Spurs defender heads home two times in first half
Everton's Jake O'Brien has goal disallowed after video check
Senegalese midfielder nets final goal in 89th minute
This loss is Everton's first at their new ground
The Tottenham defender scored on two occasions as Tottenham extended their winning streak in away games in the Premier League and handed Everton their initial loss at Hill Dickinson Stadium.
The Toffees were unbeaten in their five previous fixtures at their recently opened stadium at Bramley-Moore Dock, having departed Goodison Park behind after 133 years at the end of last season.
But Spurs captain Van de Ven pounced on two occasions from set-pieces in the first half to put their impressive record at risk, and they were failed to turn it around before Pape Matar Sarr - assisted by ex-Everton forward Richarlison - nodded in a final goal to put the game to bed.
The Everton defender thought he had equalized the scores five minutes after the defender's opener, directing a powerful header past Guglielmo Vicario from an set-piece.
Beto, in the meantime, missed a number of chances, while Vicario made a succession of excellent saves to guarantee the London club went five away games unbeaten in the English top flight.
But the VAR stepped in, advising Craig Pawson to check the score on the screen and the official decided that the winger and the attacker were in offside positions and had interfered with the Spurs keeper.
This victory moves Thomas Frank's team up to third in the Premier League, a handful of points off north London rivals and table-toppers Arsenal.
The Merseyside club stay 14th and are half a dozen points clear of the relegation zone.
Spurs breakdown: Van de Ven fulfils role at each end of the field
After a drab weekday performance in the Champions League against the French side, where they managed a mere attempts on target, Frank opted for the French striker up front instead of ex-Everton forward Richarlison.
The new arrival was unable to influence the game before being replaced for Richarlison after an hour on the field, but it emerged he wasn't needed in the final outcome.
Defender Van de Ven converted into an offensive threat to be feared.
Spurs' first goal came from a well-worked corner routine, with the midfielder heading the ball back across the six-yard box for an unmarked the defender to score.
And Ven de Ven - stepping up as skipper in the Argentine's unavailability - notched his second in added time as he outjumped Jordan Pickford to head home.
Van de Ven was just as outstanding in defence, combining well with Kevin Danso as the pair dealt excellently with the 34 crosses sent their way by the opposition.
Everton analysis: Everton lacking finishing touch
Everton's new home had been a fortress, but it seems the novelty may have worn off slightly and fans headed to the exits after Sarr's final goal for Tottenham.
The end in Everton's unbeaten home run will not be a massive worry for the manager, but their attacking woes will be.
The forward and Thierno Barry - the Everton's pair of recognised strikers - had netted just a single goal between them before Sunday's outing.
And they were failed to add to that poor tally on a wet and gloomy evening on Merseyside.
The striker's performance was epitomized when he chose to overhead kick a clear chance from close range, despite having space and opportunity to reposition for a more conventional attempt that would have challenged the keeper.
The substitute, too, failed to influence the game after coming on for Beto in the 65th minute.
It wasn't for a lack of chance. Most of the home side's offensive moves came through the winger and Ndiaye, who relentlessly whipped threatening balls into the Spurs penalty area.
What next for both teams?
Everton: The team head to the Stadium of Light in the Premier League on Monday, 3 November at 20:00 GMT.
Spurs: Spurs travel to St James' Park on Wednesday, 29 October for their fourth-round Carabao Cup match against Newcastle.